Carbamic acid, N-(2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate
CAS: 672310-15-5
Molecular Formula: C21H24N2O2
Carbamic acid, N-(2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester - Names and Identifiers
| Name | 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate |
| Synonyms | 2-N-Fmoc-aminomethyl piperidine 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate 9H-Fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate (9H-Fluoren-9-yl)Methyl (piperidin-2-ylMethyl)carbaMate (2-Piperidinylmethyl)carbamic acid 9H-fluoren-9-ylmethyl ester Carbamic acid, N-(2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester Carbamic acid, (2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester (9CI) |
| CAS | 672310-15-5 |
| InChI | InChI=1/C21H24N2O2/c24-21(23-13-15-7-5-6-12-22-15)25-14-20-18-10-3-1-8-16(18)17-9-2-4-11-19(17)20/h1-4,8-11,15,20,22H,5-7,12-14H2,(H,23,24) |
Carbamic acid, N-(2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester - Physico-chemical Properties
| Molecular Formula | C21H24N2O2 |
| Molar Mass | 336.43 |
| Density | 1.147 |
| Boling Point | 530.5°C at 760 mmHg |
| Flash Point | 274.6°C |
| Vapor Presure | 2.45E-11mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.579 |
Carbamic acid, N-(2-piperidinylmethyl)-, 9H-fluoren-9-ylmethyl ester - Introduction
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate (9H-fluoren-9-methyl (piperidine-2-methyl) carbamate) is an organic compound containing fluorene and piperidine groups in its chemical structure.
Nature:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is a white solid with good solubility. It is stable at room temperature, but decomposes at high temperatures. It ionizes under acidic conditions and can form salts with the corresponding acids.
Use:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is one of the commonly used protecting groups in organic synthesis. It can generate amino acid N-protected derivatives by reaction with amine groups, and then remove the protecting group by acid hydrolysis after the target reaction is completed. The application of this protective group is extensive, and can be used in peptide synthesis, drug synthesis and other fields.
Preparation Method:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate can be prepared by reacting 4-(piperidine-2-methyl) benzoyl chloride with 9H-fluorene-9-methanol. First, 4-(piperidine-2-methyl) benzoyl chloride is reacted with hydrofluoric acid to produce 4-(piperidine-2-methyl) benzoate. The 4-(piperidine-2-methyl) benzoate is then reacted with 9H-fluorene-9-methanol to give 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate under basic conditions.
Safety Information:
The 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is stable and safe under routine experimental conditions. However, as a chemical, it still needs to be handled and stored properly. During use, it is necessary to take appropriate personal protective measures, such as wearing gloves and protective glasses, to avoid contact with skin and eyes. At the same time, it should be operated in a well-ventilated environment to avoid inhaling its dust or vapor.
Nature:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is a white solid with good solubility. It is stable at room temperature, but decomposes at high temperatures. It ionizes under acidic conditions and can form salts with the corresponding acids.
Use:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is one of the commonly used protecting groups in organic synthesis. It can generate amino acid N-protected derivatives by reaction with amine groups, and then remove the protecting group by acid hydrolysis after the target reaction is completed. The application of this protective group is extensive, and can be used in peptide synthesis, drug synthesis and other fields.
Preparation Method:
9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate can be prepared by reacting 4-(piperidine-2-methyl) benzoyl chloride with 9H-fluorene-9-methanol. First, 4-(piperidine-2-methyl) benzoyl chloride is reacted with hydrofluoric acid to produce 4-(piperidine-2-methyl) benzoate. The 4-(piperidine-2-methyl) benzoate is then reacted with 9H-fluorene-9-methanol to give 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate under basic conditions.
Safety Information:
The 9H-fluoren-9-ylmethyl (piperidin-2-ylmethyl)carbamate is stable and safe under routine experimental conditions. However, as a chemical, it still needs to be handled and stored properly. During use, it is necessary to take appropriate personal protective measures, such as wearing gloves and protective glasses, to avoid contact with skin and eyes. At the same time, it should be operated in a well-ventilated environment to avoid inhaling its dust or vapor.
Last Update：2024-04-09 21:11:58
Supplier List
Product Name: 2-N-FMOC-AMINOMETHYL PIPERIDINE Visit Supplier Webpage Request for quotation
CAS: 672310-15-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 672310-15-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 2-N-FMOC-AMINOMETHYL PIPERIDINE Visit Supplier Webpage Request for quotation
CAS: 672310-15-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 672310-15-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History